A new strategy in treatment of neurodegenerative diseases: Neurosteroids

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Yarım G. F.

ANKARA UNIVERSITESI VETERINER FAKULTESI DERGISI, cilt.60, sa.1, ss.79-83, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 60 Sayı: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1501/vetfak_0000002557
  • Dergi Adı: ANKARA UNIVERSITESI VETERINER FAKULTESI DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.79-83
  • Anahtar Kelimeler: Neurodegenerative diseases, neurosteroid, INDUCED CELL-DEATH, TRAUMATIC BRAIN-INJURY, CHAIN CLEAVAGE ENZYME, PREGNENOLONE SULFATE, 3-BETA-HYDROXYSTEROID DEHYDROGENASE, DEHYDROEPIANDROSTERONE DHEA, PROGESTERONE CONCENTRATION, AROMATASE EXPRESSION, HIPPOCAMPAL-NEURONS, MULTIPLE-SCLEROSIS
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Steroid synthesized from cholesterol in the central nervous system independently of gonads and adrenal glands has been defined as neurosteroids. Neurosteroids are synthesized in many species of vertebrate and invertebrate nervous systems. Neurosteroids affects the many brain functions. The expression of enzymes catalyzing the synthesis of neurosteroids and the neurosteroid levels are changes in diseases of the nervous system. It has been well documented that neurosteroids protective role on the neurons. Neurosteroids reduces the disorders associated with nervous system in neurodegenerative diseases and can be used as preventive and therapeutic in these diseases.