Association between fibromyalgia syndrome and polymorphism of the IL-4 gene in a Turkish population

YİĞİT S., İNANIR A., Tekcan A., Inanir S., Tural Ş., Ates O.

GENE, cilt.527, sa.1, ss.62-64, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 527 Sayı: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.gene.2013.04.020
  • Dergi Adı: GENE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.62-64
  • Anahtar Kelimeler: Fibromyalgia syndrome, Interleukin-4 gene (IL-4), Polymorphism, PAIN, INTERLEUKIN-4
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Purpose: Fibromyalgia (FM) syndrome is a form of non-articular rheumatism characterized by long term and widespread musculoskeletal pain, morning stiffness, sleep disturbance, paresthesia, and pressure hyperalgesia at characteristic sites, called soft tissue tender points. The etiology of FM is still obscure. Genetic factors may predispose individuals to FM. Cytokines may play a role in the pathophysiology of FM. The aim of this study was to investigate the interleukin-4 (IL-4) 70 bp VNTR variations in Turkish patients with FM and evaluate if there was an association with clinical features, especially between these polymorphisms.