Ameliorative effects of paricalcitol against 1800-MHz mobile phone radiation-induced skin damage in rats

AKTAŞ S., ÇÖMELEKOĞLU Ü., Demirbag B., Kibar D., UZUN Ç., YILDIRIM M., ...Daha Fazla

TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY, sa.9-10, ss.508-525, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1080/02772248.2020.1721500
  • Dergi Adı: TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.508-525
  • Anahtar Kelimeler: 1800-MHz RF, paricalcitol, skin, oxidative stress, OXIDATIVE STRESS, GSM-1800 SIGNALS, HAIRLESS RATS, VITAMIN-D, GSM-900, MECHANISMS, PROTECTION, APOPTOSIS, RESPONSES, EXPOSURE
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

This study aimed to evaluate the protective role of paricalcitol, a vitamin D analog, against hazardous effects of 1800MHz radiofrequency (RF) radiation on the skin of male Wistar albino rats exposed one h/day for 4weeks. The maximum specific absorption rate was calculated as 0.0042W/kg. Superoxide dismutase and catalase activity, collagen bundle thickness, breaking force, energy, and stress were decreased, while malondialdehyde level and mast cell number were increased. The exposure to 1800-MHz RF radiation caused a reduction in skin biomechanical quality through oxidative stress and mast cell activation. The administration of paricalcitol caused a significant improvement.