Colistin-induced nephrotoxicity and the role of N-acetylcysteine: a retrospective cohort study

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Bozkurt İ., Sharma A., Esen Ş.

JOURNAL OF INFECTION IN DEVELOPING COUNTRIES, cilt.11, sa.11, ss.895-899, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 11
  • Basım Tarihi: 2017
  • Doi Numarası: 10.3855/jidc.9459
  • Dergi Adı: JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.895-899
  • Anahtar Kelimeler: colistin, N-acetylcycteine, nephrotoxicity, CONTRAST-INDUCED NEPHROPATHY, INTRAVENOUS COLISTIN, INFECTIONS, TRIAL, CARE, RATS
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Introduction: Colistin is associated with dose-dependent nephrotoxicity. N-acetylcycteine (NAC) may reduce the risk of concomitant acute kidney injury (AKI) due to its antioxidant properties. We report a retrospective cohort study evaluating the role of N-acetylcysteine (NAC) in the development of colistin (COL) associated nephrotoxicity.