The telomere length of gastric mucosal samples and peripheral blood lymphocytes in patients who have undergone Billroth II distal gastrectomy

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Ustaoğlu Dede M., Bektaş A., Bedir A., Bakir T., Duzgun A., Nar R., ...Daha Fazla

ARCHIVES OF MEDICAL SCIENCE, cilt.16, sa.3, ss.577-583, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.5114/aoms.2020.94656
  • Dergi Adı: ARCHIVES OF MEDICAL SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, Veterinary Science Database, Directory of Open Access Journals
  • Sayfa Sayıları: ss.577-583
  • Anahtar Kelimeler: Billroth II gastrectomy, telomere length, quantitative polymerase chain reaction, ASSOCIATION, INSTABILITY, CANCER, REFLUX, RISK, AGE
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Introduction: Telomeres play an important role in maintaining chromosomal integrity. Functional loss of telomeres increases the risk of cancer by causing genomic instability. Telomere length abnormalities have been reported in several precancerous lesions. There is no study that evaluates telomere length in Billroth II distal gastrectomy, which is known as a risk factor for gastric stump carcinogenesis, in the literature. The aim of this study was to assess the relationship between the telomere length of residual gastric mucosal samples, peripheral blood lymphocytes, and other clinicopathological parameters of patients who had undergone Billroth II distal gastrectomy.