Significance of miR-15a-5p and CNKSR3 as Novel Prognostic Biomarkers in Non-Small Cell Lung Cancer

Ergün S., GÜNEY S., TEMİZ E., Petrovic N., Güneş S.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, cilt.18, sa.12, ss.1695-1701, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 12
  • Basım Tarihi: 2018
  • Doi Numarası: 10.2174/1871520618666180718100656
  • Dergi Adı: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1695-1701
  • Anahtar Kelimeler: miRNA, ceRNA, NSCLC, miR-15a-5p, CNKSR3, prognostic biomarkers, EXPRESSION, MICRORNAS, METASTASIS, PREDICTION, PATHWAY, MIRSNPS, CASP3, SNPS
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Background: In recent years, targeted cancer treatment methods at various molecular levels have been developed for Non-Small Cell Lung Cancer (NSCLC), one of two major subtypes of lung cancer. miRNA-based clinical trials are currently the preferred targeted therapeutic strategy. Also, ceRNAs (competing endogenous RNA) would be the newest and the most effective approach to uncover novel interactions between mRNAs and miRNAs in NSCLC carcinogenesis. 'Mere are many factors influencing the efficiency of a miRNA to suppress or silence translation of the target mRNA. The most effective event is the presence of other RNAs showing ceRNA activity. These RNAs contain binding sites for specific miRNAs and enable miRNAs to bind these pseudo targets, instead of the original binding sites on the target mRNA. Therefore, the mRNA of the target gene is less affected by this miRNA, while the amount of miRNA remains the same in the media.