The Short-Term Efficacy of Biweekly Subconjunctival Bevacizumab in Diabetic Macular Edema

Yeter V., Yucel Ö., Birinci H.

CURRENT EYE RESEARCH, cilt.45, sa.5, ss.585-590, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 5
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1080/02713683.2019.1679840
  • Dergi Adı: CURRENT EYE RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.585-590
  • Anahtar Kelimeler: Subconjunctival, bevacizumab, biweekly, diabetic, edema, ENDOTHELIAL GROWTH-FACTOR, INTRAVITREAL BEVACIZUMAB, INTRAOCULAR-PRESSURE, AQUEOUS-HUMOR, RANDOMIZED-TRIAL, CATARACT-SURGERY, INJECTION, TRIAMCINOLONE, COMPLICATIONS, RANIBIZUMAB
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Purpose: To assess the effectiveness of subconjunctival bevacizumab (SB) injection every 2 weeks (biweekly) for diabetic macular edema (DME). Materials and Methods: In this prospective, non-randomized study; patients with clinically significant DME, who had central macular thickness (CMT) >300??m, were included. They received three consecutive subconjunctival injections of 0.2 ml (5 mg) bevacizumab in biweekly intervals. Macular measurements were obtained by spectral-domain optical coherence tomography. The changes in CMT, and volumes of foveal (central 1 mm), parafoveal (between 1-3 mm), and perifoveal (3-6 mm) areas were followed. Results: Totally, 35 eyes of 26 patients with DME were included in the study. Five eyes were treatment-naive and 30 eyes were treatment non-naive. The means of CMT were 440.82???101.22??m at baseline, 380.11???79.76??m at second week, 338.34???69.24??m at first month, and 330.46???74.16??m at second month. Best-corrected visual acuity (BCVA) at baseline and second month were 0.56???0.38 Log MAR (20/80) and 0.38???0.35 Log MAR (20/50), respectively. While CMT, foveal, parafoveal, and perifoveal volumes significantly decreased after SB injections, a significant improvement in BCVA was found (p