Is melatonin, leptin or their combination more effective on oxidative stress and folliculogenesis in the obese rats?

Kirikci G., ALTUNKAYNAK B. Z., Kaplan S.

JOURNAL OF OBSTETRICS AND GYNAECOLOGY, cilt.40, sa.1, ss.116-127, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1080/01443615.2019.1657816
  • Dergi Adı: JOURNAL OF OBSTETRICS AND GYNAECOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.116-127
  • Anahtar Kelimeler: Body mass index, weight loss, ovarian morphology, leptin, melatonin, stereology, HIGH-FAT, PROTECTS, CELLS, EXPRESSION, INHIBITOR, APOPTOSIS, NUMBER, HEALTH, NERVE
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

In this study, we evaluated the effects of melatonin (Mel), leptin (Lep) or melatonin and leptin treatment on ovaries in control and obese rats. The animals were divided into control (NC), melatonin (NM), leptin (NL), melatonin?leptin (NML), obese (OC), obese?melatonin (OM), obese?leptin (OL), obese?melatonin?leptin (OML) groups. Body weights, peri-ovarian fat pads, volumetric parameters and numerical values of follicles were estimated. Also, the LH receptor (LHr) immune-positivity, catalase (CAT) and the myeloperoxidase (MPO) levels were determined. The body weight and peri-ovarian fat pads were significantly decreased following Mel (p?