Radiation-associated secondary brain tumors after conventional radiotherapy and radiosurgery

Ecemis G. C., Atmaca A., Meydan D.

EXPERT REVIEW OF NEUROTHERAPEUTICS, cilt.13, sa.5, ss.557-565, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 13 Sayı: 5
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1586/ern.13.37
  • Dergi Adı: EXPERT REVIEW OF NEUROTHERAPEUTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.557-565
  • Anahtar Kelimeler: conventional radiotherapy, pituitary adenomas, radiation oncogenesis, radiosurgery, radiotherapy, GAMMA-KNIFE RADIOSURGERY, OF-THE-LITERATURE, PITUITARY-ADENOMA PATIENTS, LONG-TERM OUTCOMES, STEREOTACTIC RADIOSURGERY, VESTIBULAR SCHWANNOMA, INTRACRANIAL MENINGIOMAS, MALIGNANT TRANSFORMATION, GLIOBLASTOMA-MULTIFORME, CONSERVATIVE SURGERY
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Although there is not enough strong molecular evidence for radiation to be a causal factor for the development of secondary brain tumors, a relationship has still been found. There is a slight but significant 2-2.7% increased risk of secondary brain tumors after conventional radiotherapy. However, this risk is small and should not preclude the use of radiotherapy as an effective treatment for uncontrolled pituitary tumors. The risk of radiosurgery-associated secondary brain tumors has not been precisely determined. Taking into account the considerable number of patients who received radiosurgery worldwide and the small number of secondary brain tumors, radiosurgery seems to be a safe treatment modality. This review summarizes the pathogenesis, prevalence and characteristics of secondary brain tumors after conventional radiotherapy and stereotactic radiosurgery for pituitary adenomas.