The Alteration of Neurogenesis and Pathological Markers in Alzheimer's Disease After Deep Brain Stimulation

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Nassehi B., Kocabıçak E., Temel Y., Hescham S.

TURKISH NEUROSURGERY, cilt.32, sa.4, ss.535-548, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 32 Sayı: 4
  • Basım Tarihi: 2022
  • Doi Numarası: 10.5137/1019-5149.jtn.35598-21.2
  • Dergi Adı: TURKISH NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.535-548
  • Anahtar Kelimeler: Alzheimer?s disease, Deep brain stimulation, Neurogenesis, Neuroprotection, NUCLEUS BASALIS, ELECTRICAL-STIMULATION, ENTORHINAL CORTEX, MEMORY DEFICITS, RAT MODEL, HIPPOCAMPAL NEUROGENESIS, COGNITIVE IMPAIRMENT, THALAMIC-STIMULATION, SUBVENTRICULAR ZONE, ANTERIOR THALAMUS
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Alzheimer???s disease (AD) is the most common type of dementia that causes disabilities in memory formation and activities of daily living. Unfortunately, pharmacologic treatments have minimal and short-lasting effects on AD. With the increasing aging population, investigations into therapeutic strategies for AD that lead to a delay in disease progression would significantly reduce the global burden of AD. Deep brain stimulation (DBS) is considered therapeutic for several conditions, such as movement disorders and some psychiatric diseases. Preclinical and clinical studies that used DBS as a treatment modality demonstrate the safety of DBS in AD and suggest potential memory improvements after surgery. Nevertheless, more studies are needed to understand the therapeutic mechanism of DBS. In this review, we summarize studies on DBS in various targets for AD and discuss DBS-induced changes in neurogenesis and pathological markers in AD.