Evaluation of bee venom and hyaluronic acid in the intra-articular treatment of osteoarthritis in an experimental rabbit model

Nisbet H. Ö., Özak A., Yardımcı C., Nisbet C., Yarım M., Bayrak İ. K., ...Daha Fazla

RESEARCH IN VETERINARY SCIENCE, cilt.93, sa.1, ss.488-493, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 93 Sayı: 1
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.rvsc.2011.08.007
  • Dergi Adı: RESEARCH IN VETERINARY SCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.488-493
  • Anahtar Kelimeler: Bee venom, Hyaluronic acid, Experimental, Osteoarthritis, Radiography, Magnetic resonance, Histopathology, Rabbit, ARTICULAR-CARTILAGE THICKNESS, RESONANCE-IMAGING MRI, KNEE OSTEOARTHRITIS, MOLECULAR-WEIGHT, ARTHRITIS, MELITTIN, EDEMA, INJECTIONS, RATS, PAIN
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

The aim of this study was to investigate bee venom and hyaluronic acid in the intra-articular treatment of osteoarthritis in an experimental rabbit model. Forty-five rabbits were used and they were randomly divided into three groups (BVI, MI, and HA) and each group was divided to two subgroups to evaluate the radiologic, magnetic resonance imaging, histopathologic, and biochemical evaluation in post treatment second week (a) and twelfth week (b). Radiologically, a significant difference was observed in the HA group (P < 0.05). The MRI evaluation of at any time in group BVI(b) was found to be different. No significant differences were seen between the groups, biochemically. Histopathologically, cellularity, and orthochromasia was evident with Safranin-O in the BVI(b) and BVII(a); adhesions were seen in the BVII(a) group and clustering of chondrocyte in the HA(b) group were found to be different. Consequently, intra-articular application of HA and BV for experimental model of osteoarthritis has no significant influence upon recovery after therapy. (C) 2011 Elsevier Ltd. All rights reserved.