Early biochemical predictors of sepsis in patients with burn injury: current status and future perspectives

ERENLER A. K., Baydın A., AY M. O., Dogan G., Yasti A. C.

REVIEWS IN MEDICAL MICROBIOLOGY, cilt.31, sa.3, ss.135-143, 2020 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1097/mrm.0000000000000208
  • Dergi Adı: REVIEWS IN MEDICAL MICROBIOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Aquatic Science & Fisheries Abstracts (ASFA), CAB Abstracts, EMBASE, Veterinary Science Database
  • Sayfa Sayıları: ss.135-143
  • Anahtar Kelimeler: biomarkers, burn injury, diagnosis, sepsis, C-REACTIVE PROTEIN, ACUTE RESPIRATORY-INFECTIONS, 4G/5G PROMOTER POLYMORPHISM, GUIDED ANTIBIOTIC-THERAPY, PROCALCITONIN LEVELS, DOWN-REGULATION, PLASMA, DIAGNOSIS, BIOMARKER, COPEPTIN
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Sepsis is the leading cause of morbidity and mortality in patients with burn injury and emerges as a clinical challenge for both emergency specialists and critical care staff. Since early diagnosis and appropriate treatment are known to be the milestones of sepsis management, use of biomarkers in diagnosis is highly recommended in the initial stage of sepsis. Although currently used Procalcitonin, as a traditional marker, may accurately indicate the presence of a systemic inflammation in burn patients, there is a need for more accurate markers of sepsis in burn patients. For now, use of a combination of markers may be suggested for a more accurate diagnosis. In the near future, gene therapy may make not only early prediction, but also appropriate treatment of sepsis in burn patients possible. In this article, we aimed to clarify roles of current biomarkers in early diagnosis of sepsis in burn patients and make future reflections in this growing field. Copyright (C) 2020 Wolters Kluwer Health, Inc. All rights reserved.