Dual Infection of Fetal and Neonatal Small Ruminants with Border Disease Virus and Peste des Petits Ruminants Virus (PPRV): Neuronal Tropism of PPRV as a Novel Finding

Toplu N., Oguzoglu T. C., Albayrak H.

JOURNAL OF COMPARATIVE PATHOLOGY, cilt.146, sa.4, ss.289-297, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 146 Sayı: 4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.jcpa.2011.07.004
  • Dergi Adı: JOURNAL OF COMPARATIVE PATHOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.289-297
  • Anahtar Kelimeler: border disease, dual infection, peste des petits ruminants, pestivirus, VIRAL DIARRHEA VIRUS, TRANSPLACENTAL INFECTION, PATHOLOGICAL FINDINGS, PESTIVIRUS INFECTION, PREGNANT EWES, GOATS, CATTLE, SHEEP, TRANSMISSION, DIAGNOSIS
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Dual infection of 26 fetal and neonatal small ruminants with border disease virus (BDV) and peste des petits ruminants virus (PPRV) is reported. The animals included five aborted lamb fetuses, 19 neonatal lambs and two neonatal kids from flocks in regions of the Black Sea and the Aegean region. BDV and PPRV antigens were detected immunohistochemically in the brain, oral mucosa, intestine and lung of infected animals. Reverse transcriptase-polymerase chain reaction was used to demonstrate PPRV and BDV in samples of the spleen, lymph node, lung and brain from infected animals. On the basis of observations made, it is concluded that brain damage following intrauterine infection with BDV facilitates the passage of PPRV to the brain and results in infection of neuronal and glial cells by PPRV. (C) 2011 Elsevier Ltd. All rights reserved.