Transgenic Rat Models of Huntington's Disease

Carreira J. C., Jahanshahi A., Zeef D., Kocabicak E., Vlamings R., von Hoersten S., ...Daha Fazla

BEHAVIORAL NEUROBIOLOGY OF HUNTINGTON'S DISEASE AND PARKINSON'S DISEASE, cilt.22, ss.135-147, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1007/7854_2013_245
  • Dergi Adı: BEHAVIORAL NEUROBIOLOGY OF HUNTINGTON'S DISEASE AND PARKINSON'S DISEASE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.135-147
  • Anahtar Kelimeler: Transgenic rat model, Huntington's disease, Striatum, Basal ganglia, Behaviour, BACHD, Neuropathology, Neurophysiology, DEFICITS, MOTOR, BEHAVIOR, NUCLEUS
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Several animal models for Huntington's disease (HD) have been created in order to investigate mechanisms of disease, and to evaluate the potency of novel therapies. Here, we describe the characteristics of the two transgenic rat models: transgenic rat model of HD (fragment model) and the Bacterial Artificial Chromosome HD model (full-length model). We discuss their genetic, behavioural, neuropathological and neurophysiological features.