Genotoxicity assessment using comet assay in Behcet's disease patients

Bilgici B., Bedir A., Senturk N., Alvur M., Aydin F., Turanli A.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, cilt.578, sa.1-2, ss.170-174, 2005 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 578 Sayı: 1-2
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.mrfmmm.2005.05.011
  • Dergi Adı: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.170-174
  • Anahtar Kelimeler: genotoxicity, Behcet's disease, comet assay, single cell gel electrophoresis, DNA-DAMAGE, MALIGNANCY, CANCER, CELLS
  • Ondokuz Mayıs Üniversitesi Adresli: Hayır

Özet

Behcet's disease (BD) was originally described by Turkish dermatologist, Hulusi Behcet in 1937. BD is an inflammatory disorder of unknown cause, characterized by recurrent oral aphthous ulcers, genital ulcers, uveitis, and skin lesions. All these common manifestations are self-limiting except for ocular attacks. The aims of this study were to assess whether BD patients have more genotoxicity than healthy controls and whether colchicine (COL) treated BD patients are different from those not using COL in terms of genotoxicity.