Analysis of YKL-40 Acute-Phase Protein and Interleukin-6 Levels in Periodontal Disease

Keles Z. P., Keles G. C., Avcı B., Özkan Çetinkaya B., EMİNGİL G.

JOURNAL OF PERIODONTOLOGY, cilt.85, sa.9, ss.1240-1246, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 85 Sayı: 9
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1902/jop.2014.130631
  • Dergi Adı: JOURNAL OF PERIODONTOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1240-1246
  • Anahtar Kelimeler: Acute-phase proteins, CHI3L1 protein, human, gingival crevicular fluid, interleukin-6, periodontal diseases, serum, YKL 40 protein, human, GINGIVAL CREVICULAR FLUID, C-REACTIVE PROTEIN, SERUM YKL-40, ENDOTHELIAL DYSFUNCTION, INFLAMMATORY BIOMARKER, RHEUMATOID-ARTHRITIS, MARKER, PLASMA, PARAMETERS, CYTOKINES
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Background: YKL-40, a new acute-phase protein, is shown to be elevated in inflammatory diseases, such as rheumatoid arthritis, type 2 diabetes mellitus, and coronary artery diseases. However, there is no data indicating a relationship between YKL-40 and periodontal disease. Interleukin-6 (IL-6) is the major regulator of acute-phase protein synthesis and one of the most studied inflammatory markers in periodontal disease. The purpose of the present study is to evaluate YKL-40 and IL-6 levels in gingival crevicular fluid (GCF) and serum of patients with periodontal disease and healthy individuals.