Molecular epidemiology of Coxiella burnetii detected in humans and domestic ruminants in Turkey

Ozgen E. K., Kilicoglu Y., Yanmaz B., Ozmen M., Ulucan M., Bagatir P. S., ...Daha Fazla

VETERINARY MICROBIOLOGY, cilt.273, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 273
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1016/j.vetmic.2022.109519
  • Dergi Adı: VETERINARY MICROBIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, EMBASE, Environment Index, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Q fever, Coxiella burnetii, Cattle, Sheep, Human, MLVA, Erzurum, Samsun, Q-FEVER OUTBREAK, GENOTYPIC DIVERSITY, IDENTIFICATION, INFECTION, GOATS, SHEEP, MILK
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Q fever is a zoonotic disease that is known to be widespread throughout the world by many researches since its discovery in 1935 and it is important in terms of animal and public health. Coxiella burnetii, which is the etiological agent of the disease, is an obligate intracellular pathogen. While the disease generally manifests itself with abortion in animals, disease manifests as atypical pneumonia or granulomatous hepatitis in the acute form and as endocarditis in the chronic form in humans. Its presence in Turkey has been shown with a large number of studies. The aim of this study was to show the genotypic relationship with MLVA analysis of C. burnetii samples found in cattle, sheep and goat samples in Erzurum and Samsun Veterinary Control Institutes and blood samples collected from humans with atypical pneumonia findings. In the study, MLVA analyses of 100 positive samples from 50 cows, 41 sheep and 9 goats from Northeast Anatolia and Black Sea regions and C. burnetii positive samples found in 6 individuals with atypical pneumonia were performed. As a result of the study, it was found that 106 C. burnetii samples had belong to 16 genotype groups. It was found that genotype XVI was the most prevalent among these groups and it was seen in both regions. In addition to this, genotype IX profile was the second largest group with 83.3% (5/6) of human samples. In this study, the genotypes common in the regions were determined and a data source was created for possible outbreaks.