Studies on Synthesis and Anti-inflammatory Activities of Novel 1,2,4-Triazolo[3,4-b]-1,3,4-thiadiazines

KÖKSAL M., Ozkan I., YARIM YÜKSEL M., Bilge S. S., Bozkurt A., Erol D. D.

REVISTA DE CHIMIE, cilt.62, sa.11, ss.1069-1072, 2011 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 62 Sayı: 11
  • Basım Tarihi: 2011
  • Dergi Adı: REVISTA DE CHIMIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.1069-1072
  • Anahtar Kelimeler: Anti-inflammatory activity, NSAIDs, synthesis, triazolo-1,3,4-thiadiazines, DERIVATIVES, 1-ACYLTHIOSEMICARBAZIDES, 1,3,4-THIADIAZOLES, DESIGN
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

In this study, synthesis of a series of 3,6-diaryl-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines by the condensation of appropriate 5-(3,4-dichlorophenyl)-2-(aroylmethyl)thio-1,3,4-oxadiazoles and hydrazine hydrate in acetic acid is described. The structures of newly synthesized compounds were confirmed by IR, H-1-NMR and elemental analysis. All the compounds were evaluated for anti-inflammatory activity by determining their ability to provide protection against carrageenan-induced edema in rat paw. In addition, ulcerogenic activities of the compounds were determined. The anti-inflammatory data scoring showed that most of the compounds exhibited anti-inflamatory activity profile at 100 mg/kg.