Coexistence of HLA-B*08 and HLA-B*18 in four siblings with lichen sclerosus

Senturk N., Aydin F., Birinci A., Yildiz L., Canturk T., Durupinar B., ...Daha Fazla

DERMATOLOGY, cilt.208, sa.1, ss.64-66, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 208 Sayı: 1
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1159/000075049
  • Dergi Adı: DERMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.64-66
  • Anahtar Kelimeler: lichen sclerosus, human leukocyte antigens, genetics, autoimmunity, ET-ATROPHICUS, HLA ANTIGENS, ASSOCIATION, CHILDHOOD, SYSTEM
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Background: Lichen sclerosus (LS), is characterized by localized patches of atrophy and whitening of the skin. The cause of LS remains unknown, but genetic, hormonal, immunologic factors and autoimmune mechanisms have been incriminated. There are conflicting data regarding the association between LS and human leukocyte antigens (HLA). Methods: We have analyzed the HLA alleles of a family, in which 4 of 5 children have lichen sclerosus. Results: HLA-B*08 and HLA-B*18 alleles were detected in children with LS, but not in a healthy sister. None of the patients had autoimmune disease. Conclusion: In our opinion, coexistence of these two alleles may play a role in the development of LS. Copyright (C) 2004 S. Karger AG, Basel.