SOX4 expression levels in urothelial bladder carcinoma

Güneş S., Yegin Z., Süllü Y., Buyukalpelli R., Bagci H.

PATHOLOGY RESEARCH AND PRACTICE, cilt.207, sa.7, ss.423-427, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 207 Sayı: 7
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.prp.2011.05.005
  • Dergi Adı: PATHOLOGY RESEARCH AND PRACTICE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.423-427
  • Anahtar Kelimeler: Bladder carcinoma, SOX4 gene, Gene expression, GENE AMPLIFICATION, IN-VITRO, MOLECULAR MARKERS, CANCER, OVEREXPRESSION, MEDULLOBLASTOMA
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

High levels of SOX4 gene expression have been reported in a variety of human cancers. The protein may function in the apoptosis pathway, leading to cell death as well as to tumorigenesis. The aim of this study was to investigate the levels of SOX4 expression in bladder cancer. Urinary bladder tumor samples were obtained from 57 bladder cancer and 13 normal bladder biopsies. The levels of SOX4 expression in bladder cancer were determined by immunohistochemistry and real-time PCR. SOX4 gene expression was increased 2.2 times in bladder tumors as compared with normal tissue. The presence of protein was confirmed by immunostaining. There were significant differences between immunostaining of bladder tumors and normal bladder tissue (P=0.001). The present data suggest that SOX4 gene may have a role in bladder cancer tumorigenesis. (C) 2011 Elsevier GmbH. All rights reserved.