Atıf İçin Kopyala
Kayhan S., Guzel A., Duran L., Tütüncü Ş., Guzel A., Gunaydin M., ...Daha Fazla
JOURNAL OF THORACIC DISEASE, cilt.5, sa.5, ss.641-649, 2013 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
5
Sayı:
5
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Basım Tarihi:
2013
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Doi Numarası:
10.3978/j.issn.2072-1439.2013.09.20
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Dergi Adı:
JOURNAL OF THORACIC DISEASE
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Sayfa Sayıları:
ss.641-649
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Anahtar Kelimeler:
Animal model, anti-inflammatory, Il-6, lungs, superoxide dismutase (SOD), RHEUMATOID-ARTHRITIS, PATHOGENESIS, INFLAMMATION, MECHANISM, THERAPY, MODELS
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Ondokuz Mayıs Üniversitesi Adresli:
Evet
Özet
Purposes: Pulmonary fibrosis is a rare and progressive lung disease with a high mortality rate. The treatment regimens still fail to recover the disease. Leflunomide (LEF) is an immunomodulatory agent with antiproliferative activity that is used for the treatment of rheumatoid arthritis. The purpose of the study is to investigate the potential therapeutic efficacy of LEF in bleomycin (BLM) induced pulmonary fibrosis.