Protective Effect of Lycopene against Radiation-induced Hepatic Toxicity in Rats

Meydan D., Gürsel Ş. B., Bilgici B., Can B., Ozbek N.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, cilt.39, sa.4, ss.1239-1252, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 4
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1177/147323001103900412
  • Dergi Adı: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1239-1252
  • Anahtar Kelimeler: LYCOPENE, IONIZING RADIATION, OXIDATIVE DAMAGE, ANTIOXIDANT, LIVER, NORMAL TISSUE-INJURY, INDUCED DNA-DAMAGE, OXIDATIVE STRESS, GAMMA-RADIATION, ANTIOXIDANT ENZYMES, IONIZING-RADIATION, LIVER, IRRADIATION, ORGAN, PREVENTION
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

The radioprotective effect of lycopene against liver damage was investigated in 80 female Sprague Dawley rats (10 per group). Early-group rats included: controls (group 1), lycopene (group 2), radiotherapy alone (group 3), and lycopene + radiotherapy (group 4). Lycopene (5 mg/kg per day) was administered orally for 7 days; single-fraction 8 Gy abdominopelvic radiotherapy was administered on day 8. Early-group rats were sacrificed on day 10. Late-group rats (groups 5 - 8) underwent treatment with the same regimens but, in groups 6 and 8, lycopene was administered until all rats were sacrificed, 60 days postradiotherapy. Liver malondialdehyde levels increased significantly and glutathione (GSH) levels, GSH-peroxidase (GSH-Px) and superoxide dismutase (SOD) activity decreased significantly in radiotherapy versus control groups. In lycopene + radiotherapy groups, malondialdehyde levels decreased significantly and GSH levels, GSH-Px and SOD activity increased significantly compared with radiotherapy groups. No significant between-group histopathological differences were observed in early groups; in late groups, histopathological changes increased significantly in the radiotherapy group versus control group. A significant decrease in histopathological changes occurred in the lycopene + radiotherapy group compared with the radiotherapy group. Lycopene supplementation significantly reduced radiotherapy-induced oxidative liver injury.