Akademik Veri Yönetim Sistemi
Turkish Journal of Medical Sciences, cilt.30, sa.2, ss.109-113, 2000 (Scopus)
In recent years, Endothelin-1 (ET-1), Platelet Activating Factor (PAF) and thromboxane have been considered responsible for the pathogenesis of acute cyclosporine nephrotoxicity (ACN). The aim of this study was to investigate the effects of the PAF antagonist gingko glycosid (EGb 761) on both renal histology and ET-1 and Nitric Oxide (NO) levels in experimental ACN. This study was carried out on 30 albino rabbits, divided into three groups. They were: group A (n=10) the control, group B (n=10), which was given intravenous cyclosporine (15mg/kg/day) and group C (n=10), which was given oral gingko glycosid (2.5mg/kg/day) in addition to cyclosporine. Plasma ET-1 and NO levels and renal histology were investigated in all of the groups. Data analysis was performed by Kruskall-Wallis one-way Anova and Mann Whitney-U tests. Plasma ET-1 levels in group B and C were higher than in the controls (p<0.0002, p<0.0002, respectively). Plasma NO levels in groups B and C were lower than in the controls (p<0.0002, p<0047, respectively). However, group C had high NO levels and low ET-1 levels compared to group B (p<0.004, p<0.0002, respectively). Renal histological findings of ACN were observed in group B, and to a lesser extent in group C. Consequently, it was established that the PAF antagonist Gingko glycosid Egb 761 partially improved both the renal histology and plasma ET-1 and NO levels in experimental ACN.