ACAN Gene VNTR Polymorphism and Intervertebral Disc Degeneration in a Turkish Population

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Oz T., Kaya I., NURSAL A. F., AYDIN H. E., DEMİR O., YİĞİT S.

HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI, cilt.58, sa.4, ss.309-314, 2020 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58 Sayı: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4274/haseki.galenos.2020.6006
  • Dergi Adı: HASEKI TIP BULTENI-MEDICAL BULLETIN OF HASEKI
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.309-314
  • Anahtar Kelimeler: Intervertebral disc degeneration, aggrecan, VNTR, PCR, AGGRECAN GENE, VARIABLE NUMBER, ASSOCIATION
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Aim: Intervertebral disc degeneration (IVDD) is caused by several genetic and environmental factors. Aggrecan is the major component of intervertebral disk matrix proteoglycan with multiple functional domains. The aim of this study was to investigate the possible association between ACAN (coding aggrecan) gene variable number tandem repeat (VNTR) polymorphism and susceptibility to IVDD.