Synthesis and cytotoxic activity of some 1,2,4-triazoline-3-thione and 2,5-disubstituted-1,3,4-thiadiazole derivatives

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KARAKUŞ S., ÇORUH U., Barlas-Durgun B., Vazquez-Lopez E. M., ÖZBAŞ S., Akbuga J., ...Daha Fazla

MARMARA PHARMACEUTICAL JOURNAL, cilt.14, sa.2, ss.84-90, 2010 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 2
  • Basım Tarihi: 2010
  • Doi Numarası: 10.12991/201014454
  • Dergi Adı: MARMARA PHARMACEUTICAL JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Sayfa Sayıları: ss.84-90
  • Anahtar Kelimeler: Cytotoxic activity, 1,2,4-triazoline-3-thione, 2,5-disubstituted-1,3,4-thiadiazole, mtt assay, x-ray crystallograpy
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

In this search, a series of 5-[4-(4-fluorobenzoylamino) phenyl]-2-substitutedamino- 1,3,4-thiadiazole (2a-g) and 5-[4-(4-fluorobenzoylamino) phenyl]-4-substituted-2,4-dihydro- 3H-1,2,4-triazo-le-3-thione (3a-f) derivatives were synthesized and characteristed by elemental analysis, UV-visible, IR, H-1-NMR, MS spectral data and X-ray crystallograpy (3b). Cytotoxic activity of six prototype compounds (2a, 2d, 2e, 3a, 3d and 3e) were evaluated by using HeLa (ATCC CCL-2) and normal cell lines according to procedures of MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] Assay [Cell Proliferation Kit I (MTT) Roche-Germany].