Proton magnetic resonance spectroscopy of the anterior cingulate gyrus and caudate nucleus in schizophrenia patients versus healthy controls

İncesu L., Baydin M., Aslan K., Diren B., Sahin H., Böke Ö., ...Daha Fazla

NEURAL REGENERATION RESEARCH, cilt.6, sa.6, ss.467-473, 2011 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 6 Sayı: 6
  • Basım Tarihi: 2011
  • Doi Numarası: 10.3969/j.issn.1673-5374.2011.06.012
  • Dergi Adı: NEURAL REGENERATION RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.467-473
  • Anahtar Kelimeler: schizophrenia, magnetic resonance spectroscopy, anterior cingulate gyrus, caudate nucleus, neurocognitive test, DORSOLATERAL PREFRONTAL CORTEX, BASAL GANGLIA, MEDICATED SCHIZOPHRENICS, ONSET SCHIZOPHRENIA, NEURONAL VIABILITY, CHILDHOOD-ONSET, METABOLIC-RATE, IN-VIVO, BRAIN, CHOLINE
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Proton magnetic resonance spectroscopy (H-1-MRS) permits the assessment of cerebral neurometabolites, such as N-acetylaspartate, choline, and creatine, in vivo and has been used to study schizophrenia. The present study used H-1-MRS to compare the spectroscopy change of N-acetylaspartate, creatine, and choline metabolite levels in the anterior cingulate and caudate nucleus of both schizophrenia patients and healthy controls, as well as between the left and right cerebral hemispheres in the schizophrenia patients. Results showed that N-acetylaspartate and creatine metabolite levels in the left anterior cingulate gyrus were significantly lower in the schizophrenia patients than in the healthy controls, indicating hypometabolism. In addition, choline concentration in the left caudate nucleus of schizophrenia patients was significantly lower than in the right caudate nucleus, indicating that it is necessary to study the cerebral lateralization of H-1-MRS in schizophrenia patients.