Evaluation of hepatoprotective activity of Bergamot orange in rats

Karaca M., Ilhan F., Altan H., Him A., Tütüncü M., Özbek H.

Eastern Journal of Medicine, cilt.10, sa.1-2, ss.1-4, 2005 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 1-2
  • Basım Tarihi: 2005
  • Dergi Adı: Eastern Journal of Medicine
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.1-4
  • Anahtar Kelimeler: Bergamot orange, Carbon tetrachloride, Hepatoprotective activity, Rats
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Essential oil extract of Bergamot orange (BO) was investigated for its hepatoprotective effect on carbon tetrachloride-induced hepatotoxicity in rats. Six different groups were established. Silibinin was used as the reference agent. BO significantly reduced the serum ALT level when compared to CCl 4 group while it did not affect the serum AST level. The histopathological findings did not show any significant difference between the BO and CCl 4 groups. The results suggest that BO has a weak hepatoprotective effect in carbon tetrachloride induced acute liver toxicity.