The effect of ethanol on lipid peroxidation and glutathione level in the brain stem of rat

Ağar E., Bosnak M., AMANVERMEZ R., Demir S., Ayyıldız M., Celik C.

NeuroReport, cilt.10, sa.8, ss.1799-1801, 1999 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 8
  • Basım Tarihi: 1999
  • Doi Numarası: 10.1097/00001756-199906030-00032
  • Dergi Adı: NeuroReport
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1799-1801
  • Anahtar Kelimeler: Antioxidants, Brain stem, Glutathione, Lipid peroxidation, Vitamin E
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

The effects of ethanol consumption on the levels of lipid peroxidation (TBARS) and reduced glutathione (GSH) in the brain stem of male rats were investigated. The rats randomly divided into eight groups: control, 10%, 25%, 35% ethanol-consuming groups and four groups given vitamin E. Brain stem GSH levels were significantly decreased by 39.74%, 61.57%, 78.23% in rats consuming 10%, 25% and 35% ethanol, respectively. The level of TBARS was increased six-fold, 12-fold and 17-fold in these groups when compared with the control group. The administration of vitamin E (100 mg/kg/day, i.p) to ethanol-consuming rats for 20 days caused a significant increase in glutathione levels and a significant decrease in lipid peroxidation.