Investigation of anti-inflammatory activity of bergamot oil

Karaca M., Özbek H., Him A., Tütüncü M., Akkan H. A., Kaplanoǧlu V.

European Journal of General Medicine, cilt.4, sa.4, ss.176-179, 2007 (Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 4 Sayı: 4
  • Basım Tarihi: 2007
  • Doi Numarası: 10.29333/ejgm/82525
  • Dergi Adı: European Journal of General Medicine
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.176-179
  • Anahtar Kelimeler: Anti-inflammatory activity, Bergamot oil, Carrageenan-oedema, Citrus aurantium subsp. bergamia
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Aim: Essential oil of Bergamot (BO) was investigated for anti-inflammatory activity using carrageenan-induced rat paw oedema test. Methods: For the anti-inflammatory activity measurement six different groups were established and BO was administered in three different doses: 0.025, 0.05 and 0.10 mL/kg. Indomethacin was used as a reference agent. Results: It was found that reduction in the inflammation was 95.70% with indomethacin, 27.56% with 0.025 mL/kg BO, 30.77% with 0.05 mL/kg BO and 63.39% with 0.10 mL/kg BO. Indomethacin showed the strongest anti-inflammatory activity among the drugs used. The strongest anti-inflammatory activity of BO was seen with 0.10 mL/kg dosage. Median effective dose (ED50) value of BO was found to be 0.079 mL/kg. Conclusion: The results showed that BO posseses promising anti-inflammatory effect.