Peripheral nerve and diclofenac sodium: Molecular and clinical approaches

KAPLAN A. A., Yurt K. K., Deniz O. G., Altun G.

JOURNAL OF CHEMICAL NEUROANATOMY, cilt.87, ss.2-11, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 87
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.jchemneu.2017.08.006
  • Dergi Adı: JOURNAL OF CHEMICAL NEUROANATOMY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2-11
  • Anahtar Kelimeler: Nonsteroidal anti-inflammatory drugs, Neuropathic pain, Cyclooxygenase, Schwann cells, Diclofenac sodium, NONSTEROIDAL ANTIINFLAMMATORY DRUG, NEUROPATHIC OROFACIAL PAIN, PRENATAL EXPOSURE, TOPICAL DICLOFENAC, SCIATIC-NERVE, OPTIC-NERVE, MECHANICAL ALLODYNIA, CHEMICAL IRRITATION, SPINAL-CORD, MOUSE MODEL
  • Ondokuz Mayıs Üniversitesi Adresli: Evet

Özet

Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most frequently prescribed medications worldwide. Diclofenac sodium (DS), one of these NSAIDs, has a high specificity for arachidonic acid-degrading cyclooxygenase (COX)-2 enzymes. This drug can be used to relieve neuropathic pain. In this review, we examine the relevant researches, including in vivo, animal, and clinical human studies, with the aim of understanding the effect of DS on the peripheral nerves. In injured nerves, COX-2 is potently upregulated around the injury site. When a nerve is damaged, both COX-1 and COX-2 expression is increased in macrophages and Schwann cells. In addition, COX inhibitors can promote axonal outgrowth in cultured neurons. Neuropathic pain occurs after injury and leads to dysfunction of the peripheral nervous system. NSAIDs can modulate the nociceptive and inflammatory pain pathways and control neuropathic pain. DS may accelerate nerve regeneration and its effects on healing, as well as causing deleterious effects in the developing nerves. DS teratogenicity disrupts myelin sheath thickness and axon structure. Understanding the possible benefits and limitations of DS and specific conditions such as prenatal use will be of benefit in clinical practice.